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Substantial Matters: Life & Science of Parkinson’s


In Substantial Matters: Life & Science of Parkinson’s, host Dan Keller, PhD, interviews Parkinson’s experts to highlight treatments and techniques that can help you live a better life now, as well as research that can bring a better tomorrow. Episodes focus topics relevant to your daily life, including new levodopa delivery methods, exercise, clinical trials, nutrition and more! Learn more about our episodes and speakers at parkinson.org/Podcast. Follow and rate us on your favorite podcast platform to be notified when there’s a new episode! Let us know what other topics you would like us to cover by visiting parkinson.org/feedback.

Mar 5, 2024

Carbidopa-levodopa is considered the “gold standard treatment” for Parkinson’s disease. Levodopa works to replace levels of dopamine in the brain, thereby alleviating PD symptoms, while Carbidopa works to reduce adverse effects in the rest of the body. Although years have passed since the creation of this treatment, it is still commonly known to be an effective drug for reducing PD symptoms in a majority of people living with Parkinson’s.

In this episode, we hear from Dr. Emily Peron, PharmD and Dr. Leslie Cloud, MD from Virginia Commonwealth University*. They discuss how and why carbidopa-levodopa continues to be a standard treatment for PD, long-term use considerations, its different forms, and when to recognize the need for potential medication adjustments.

*Denotes a Parkinson's Foundation Center of Excellence